If the angle off the spot ball is conducive to sending the 4ball off the 10ball cross corner then it may be a consideration, if not then for me it's not an option. Lets assume that the "two way shot" is not available, then what is your shot?
For those who don't like shooting the 6ball off the spot I like banking the 6ball toward the 2ball and positioning the cue ball near the diamond on the bottom rail left of the chalk. This shot if hit well will possibly create a two ball cluster and take away both the 2ball and 6ball as balls "in play"and also will not give up a shootable ball for Reyes to pocket.
The balls in this particular lay out are all in play, understanding this you must then be particular on which ball you shoot and what your plan, or objective is. My shot with banking the 6ball toward the 2ball takes the 6ball out of play and possibly ties up the 2ball as well. Plus it doesn't leave a bank for Reyes to start a trap off of. Certain positions like the one here where all balls are in play will take some work to position balls "out of play" you must be particular with your first shot not to leave a return shot that puts you on defense ..clearing balls from your opponents pocket.
You also must be cognizant of where you position the cue ball off the 6ball. You don't want to position the cue ball directly under the 10ball near the bottom rail, that leave allows your opponent to play off the 10ball and send the cue ball to the top right quadrant of the table utilizing the striped ball located in the center of the table as a blocker protecting the balls on his side. Take away that angle by positioning the cue ball where I mentioned..near the chalk on the bottom rail.
Roll up your sleeves and go to work and make it tough on your opponent by not leaving him a shot to either get back in the game or a shot to keep his stroke loose. If you know what I mean. Break his ass down, for lack of a better expression.
Dr. Bill